Organic Chemistry
Consulting Services

// Small Molecule Design & Synthesis Expertise

Professional organic chemistry consulting with 10+ years of experience in medicinal chemistry, custom synthesis, and pharmaceutical route optimization. From concept to commercialization.

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Expert Services

// Comprehensive Organic Chemistry Solutions

Custom Synthesis

Design and execute complex multi-step syntheses for pharmaceutical intermediates, natural products, and specialty chemicals. Expert in asymmetric synthesis and stereochemistry control.

Route Design

Retrosynthetic analysis and de novo synthetic route design for complex targets. Evaluating multiple pathways for feasibility, scalability, and cost before committing lab time.

Route Optimization

Streamline existing synthetic pathways to reduce steps, improve yields, and minimize costs. Process chemistry expertise for scale-up and manufacturing optimization.

About Dr. Chen Wei

// Organic Chemistry PhD with Industrial Experience

Dr. Chen Wei
PhD in Organic Chemistry - Peking University (2012)
Senior Scientist - Novartis (2012-2018)
Lead Chemist - BeiGene (2018-2022)
20+ Publications in J. Am. Chem. Soc., Angew. Chem.
15+ Patents in Pharmaceutical Chemistry
Consultant for 50+ Biotech Companies
English, Chinese, German Fluent

Selected Projects

// Case Studies & Success Stories

Synthesis
Optimizationbr

API Synthesis Optimization

Redesigned a 12-step synthesis route for a cardiovascular drug API, reducing to 6 steps with 45% overall yield improvement and 60% cost reduction. Key improvements included telescoped reactions and elimination of chromatographic purifications.

Process Chemistry Scale-up Cost Reduction
Natural Product
Structure

Natural Product Total Synthesis

First asymmetric total synthesis of a marine alkaloid with potent anti-cancer activity. 15-step route featuring innovative cascade cyclization reaction and excellent stereochemical control throughout the sequence.

Total Synthesis Stereochemistry Method Development
Compound Library
Preview

Pharmaceutical Intermediate Library

Designed and synthesized a focused library of 200+ heterocyclic compounds for a kinase inhibitor program, leading to 3 clinical candidates. Structure-activity relationships guided optimization strategy.

Med Chem SAR Drug Discovery
Green Chemistry
Route

Green Chemistry Implementation

Developed environmentally friendly synthesis route replacing toxic reagents and reducing waste by 80% for a diabetes treatment manufacturing process. Achieved same efficiency with safer reagents.

Green Chemistry Sustainability Manufacturing
Chiral Auxiliary
Design

Chiral Auxiliary Development

Designed novel chiral auxiliary for enantioselective synthesis of β-amino acids, achieving >95% ee with broad substrate scope and easy recovery. Patent application filed for this innovative methodology.

Asymmetric Synthesis Methodology Chirality
Alternative
Synthesis Route

Freedom-to-Operate Route Design

Developed alternative synthetic routes for blockbuster drug to avoid patent restrictions while maintaining cost-effectiveness for generic manufacturing. Successfully passed regulatory review.

Generic Drugs IP Strategy

Molecular Cases

// Molecular Cases & Synthesis Requirements

313490-26-5

25g

50637-61-1

5g

52497-37-7

50g

2245953-18-6

95% +

40909-95-3

2841352-43-8

95% +

20g

Client Feedback

// What Collaborators Say

Dr. Chen redesigned our route in six weeks and cut our COGS by nearly a third without touching the impurity profile. Communication was direct and the documentation was audit-ready from day one.

VP of Chemistry — Clinical-Stage Biotech, United States

We have relied on this team for several critical intermediates in our oncology pipeline. Their efficiency in scaling up from milligrams to kilograms is remarkable. They consistently deliver samples 1-2 weeks ahead of our projected timelines, which has significantly accelerated our preclinical development.

Co-Founder & CSO — Small Molecule Startup, Europe

We approached them with a challenging chiral synthesis that several other CROs declined due to low yields. Their chemistry team not only optimized the route to achieve over 95% ee but also provided us with thorough characterization data.

Director of Process Chemistry — CDMO, Asia-Pacific

Collaboration Process

// How We Work

01

Free Consultation

Discuss your target molecule, timeline, and constraints.

02

NDA Signature

Mutual confidentiality agreement signed before any structures or data are shared.

03

Proposal & Quote

Detailed technical proposal with scope, milestones, and transparent pricing.

04

Project Execution

Hands-on synthesis or analysis work, with progress updates at each checkpoint.

05

Delivery

Final compounds and documentation handed over, with follow-up support as needed.

Frequently Asked Questions

// Common Questions Before Getting Started

What size of project do you take on?

Any size. This ranges from a focused route feasibility review taking a few days, to multi-month custom synthesis and route optimization programs. Scope and timeline are defined together during the initial consultation, so there is no minimum project size requirement.

Do you work remotely, or do you need to be on-site?

All work is conducted remotely. Route design, retrosynthetic analysis, and optimization strategy are delivered as detailed reports and documentation. For projects requiring hands-on synthesis, execution can be coordinated with your in-house lab or a partner CDMO, with guidance provided throughout.

How is confidentiality handled?

A mutual NDA is signed before any target structures, data, or project details are shared. All materials are handled under strict confidentiality, and data is not retained or reused beyond the scope of the engagement.

How long does it take to receive a proposal and quote?

Following the initial consultation, a detailed technical proposal with scope, timeline, and pricing is typically delivered within 2-3 business days.

How is pricing structured?

Pricing depends on project scope and can be structured hourly, per milestone, or as a fixed project fee. This is discussed transparently as part of the proposal, with no hidden costs.

How quickly do you respond to inquiries?

All inquiries are answered within 24 hours.

Let's Collaborate

// Ready to Start Your Next Project?

Email

[oriwoodwild@gmail.com]